https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Betamethasone: a neuroactive steroid deficit and adverse effects in the brain? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6907 Wed 11 Apr 2018 16:26:58 AEST ]]> Effect of pre and postnatal neurosteroid therapy on neurodevelopment and behaviour https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31457 Wed 11 Apr 2018 13:05:34 AEST ]]> Primary biliary cholangitis in pregnancy: A systematic review with meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52158 Wed 04 Oct 2023 10:51:24 AEDT ]]> Fetal kidney charts of a novel measurement of the renal parenchymal thickness to evaluate fetal kidney growth and potential function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39922 Thu 30 Jun 2022 11:55:31 AEST ]]> Administration of progesterone throughout pregnancy increases maternal steroids without adverse effect on mature oligodendrocyte immunostaining in the guinea pig https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36998 Thu 30 Jul 2020 16:59:13 AEST ]]> Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45201 P = 3.96 x 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.]]> Thu 27 Oct 2022 15:06:39 AEDT ]]> Determinants of perinatal outcomes in dialyzed and transplanted women in Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51367 10-fold higher odds of preterm birth and low birthweight and 1.8- to 4.6-fold increased odds of other adverse outcomes. In transplanted women, mediation analysis revealed that pregnancy-induced hypertension contributed only a modest proportional effect (2.5%–11.2%) on adverse outcomes. Conclusion: Maternal dialysis and transplantation conferred excess perinatal morbidity, particularly for preterm babies, and even in women with good preconception allograft function. Pregnancy-induced hypertension is not the predominant determinant of perinatal morbidity. Preconception counseling of women with kidney disease should encompass discussion of perinatal complications.]]> Thu 02 May 2024 15:48:24 AEST ]]>